User blog comment:Foreborn/Call of Juarez: The Cartel New Trailer/@comment-3436492-20110520111037

Actually, you could use fists as a weapon anytime after you unlocked (It's not necessarily a good idea though, unless you are playing Easy.)

OT: From the trailers and gameplay interviews, it looks like there is "Door-Busting" Concentration Mode, and enemies glow like in Bound in Blood. Also it looks like weapons will have different models (Like the AK in Medal of Honor). For example, the SPAS-12 Shotgun in one screen shows it without a stock, and an interview video shows one with the stock unfolded.